Job Description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life‑changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

We are seeking a highly skilled scientist and teammate to join our Medicinal Chemistry group located in South San Francisco, CA. If you’re ready to push the boundaries of what is possible in synthetic chemistry and drug discovery programs, from early lead generation to identification of clinical candidates, then we encourage you to apply for this exciting opportunity with the Lilly Small Molecule Discovery Group.

• Apply and create innovative synthetic methodologies: Enable novel small molecule design, solve complex synthetic challenges, and inform fast‑paced SAR iterations through the proposal and execution of synthetic routes in the laboratory.
• Design and synthesize novel small molecules: Optimize lead compounds by improving potency, selectivity, physicochemical properties and DMPK to meet the desired target product profiles required to deliver high‑quality medicines.
• Leverage world‑class structure‑based drug design technologies: Collaborate with expert colleagues in computational chemistry and biophysics to characterize protein‑ligand interactions and gain key insights supporting de‑novo molecular design.
• Collaborate across fields: Interact with scientists in areas such as pharmacology, translational science, ADME, and toxicology to address specific program needs, and provide Medicinal Chemistry perspectives.

Minimum Requirements:

• PhD in organic chemistry
• Masters with 7–10+ years of experience

Skills/Preferences:

• Strong Synthetic Organic Chemistry skills with deep and extensive working knowledge of modern synthetic chemistry methodologies, experimental work, isolation/purification techniques and structural analysis of synthetic organic molecules.
• Ability to maintain awareness of latest literature of chemical transformations.
• Scientific creativity and ability to work independently solving problems through careful experimental design, analysis of complex data sets and mechanistic insight.
• Robust track record of scientific contributions including peer reviewed publications, patents and presentations.
• Excellent English language oral and written communication skills, ability to engage highly effectively as teammate in a multidisciplinary and international environment.
• Proficient use of Microsoft Office applications as well as Scifinder, Reaxys or other scientific data tools to identify relevant scientific literature.
• Strong work ethic, scientific curiosity, and a can‑do, will‑do attitude.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $133,500 - $217,800.

Full‑time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending account); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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